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Craig Story

Craig Story

Professor of Biology

Director, Pre-Health Professions

Director, Pastors and Science Project

B.S. Gordon College
Ph.D. in Molecular Biology, Brandeis University Post-Doc at MIT and Harvard Medical School Under Hidde L. Ploegh

Areas of expertise:


My research interests have centered around immunology and molecular biology. In graduate school at Brandeis University, I cloned and studied the transporter protein, called FcRn, that carries IgG antibodies across the human placenta under Dr. Neil E. Simister.

Subsequent to my graduate work, new roles the antibody transporter have been discovered—it extends the serum half-life of albumin as well.

I also spend a good deal of my time doing pre-health advising, also known as "pre-med" advising. It's a great part of my job to be able to write up the fine accomplishments of our students for medical, dental, PA and other schools. It's never hard to find great things to say about our wonderful students.

In 2014 and 2015, I offered a course for Pastors to come and learn about Modern Science. This "Pastors, Science and Faith" course was funded by a grant from The BioLogos Foundation. It was so wonderful to be able to share the amazing world of modern science with pastors and discuss issues of science with them. We will be offering the course one more time in 2016, please recommend it for your pastor.

My postdoctoral work was under Dr. Hidde L. Ploegh at MIT and Harvard Medical School. Dr. Ploegh is currently at the Whitehead Institute back at MIT. I rejoined his research group for my Fall '06 Sabbatical. The lab continues to study aspects of immune function using a molecular and biochemical approach. During this sabbatical I worked closely with Dr. J. Christopher Love, helping to optimize a new system for analyzing the secretions of individual cells within a diverse population. Results of my work on the microengraving system with the Ploegh and Love labs were published in PNAS, Nature Protocols, and Journal of Immunological Methods.

In Fall 2011, I spent sabbatical time working in Chris Love's new lab in the Koch Institute for Integrative Cancer Research at MIT. I continue to develop the microengraving platform as a tool for use in immunological studies at Gordon College, in collaboration with the Love lab. I am also working on "new and improved" versions of antibody proteins. At the right is a print of antibody spots viewed with a slide scanner. 

In Spring 2015, our department is proud to introduce some new equipment, including an Olympus laser scanning confocal microscope and two new IX-81 scopes, a Millipore Guava 5HT flow cytometer, and a Bio-Tek Cytation 3 Imaging Plate Reader. The cell culture room has doubled in size as well. These new facilities and equipment were funded by a grant from the Massachusetts Life Sciences Consortium (MLSC) to help prepare students for fields of medicine and biotechnology. During the summer, finally our animal facility has been built out. We are working to establish protocols and committees to allow us to use this new space most effectively. 

Selected Publications

Story, C. M. (2009) The God of Christianity and the G.O.D. of Immunology: Chance, Complexity and God’s Action in Nature. Perspectives on Science and Christian Faith 61, 221-232. This work originally presented at Venice Summer School on Science and Religion: God and the Laws of Nature, 27 May-1 June, 2008.

Ogunniyi, A. O., Story C. M., Papa, E., Guillen, E., and Love, J. C. (2009) Screening individual hybridomas by microengraving to discover monoclonal antibodies. Nature Protocols 4, 767-782.

Ronan J. L., Story, C. M., Papa, E., and Love, J. C. (2009) Optimization of microengraving method for the detection of antibodies secreted from individual primary splenocytes. J Immunol Methods 340, 164-169.

Story, C. M., Papa E., Hu, C. A., Ronan, J. L., Herlihy, K., Ploegh H. L., and Love, J. C. (2008) Profiling antibody responses by multiparametric analysis of primary B cells. Proc Natl Acad Sci, USA 105, 17902-17907.

Fiebeger, E., Story, C., Ploegh, H. L. and Tortorella, D. (2002) Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. EMBO J. 21, 1041-1053.

Swann, S. A., Williams, M., Story, C. M., Bobbitt, K. R., Fleis, R., and Collins, K. L. (2001) HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway. Virology 282, 267-277.

Story, C. M., Furman, M. H., and Ploegh, H. L. (1999) The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products. Proc Natl Acad Sci USA 96, 8516-21.

Shamu, C. M., Story, C. M., Rapoport, T., and Ploegh, H. L. (1999) The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. J Cell Biol 147:45-58.

Story, C. M., and Ploegh, H. L. (1999). MHC class I and II. in: "Guidebook to the extracellular matrix, anchor, and adhesion proteins." T. Kreis and R. Vale Eds. Oxford University Press.

Tortorella, D., Story, C. M., Huppa, J. B., Wiertz, E. J., Jones, T. R., and Ploegh, H. L. (1998). Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential. J Cell Biol 142, 365-76.

Simister, N. E., and Story, C. M. (1997). Human placental Fc receptors and the transmission of antibodies from mother to fetus. J Reprod Immunol 37, 1-23.

Simister, N. E., Israel, E. J., Ahouse, J. C., and Story, C. M. (1997). New functions of the MHC class I-related Fc receptor, FcRn. Biochem Soc Trans 25, 481-6.

Simister, N. E., Story, C. M., Chen, H. L., and Hunt, J. S. (1996). An IgG-transporting Fc receptor expressed in the syncytiotrophoblast of human placenta. Eur J Immunol 26, 1527-31.